Nuclear pore complexes: dynamics in unexpected places

J Cell Biol. 2001 Jul 9;154(1):17-20. doi: 10.1083/jcb.200106071.

Abstract

In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.

Publication types

  • Comment
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Basement Membrane / chemistry
  • Cell Nucleus / metabolism*
  • Models, Biological
  • Nuclear Envelope / metabolism*
  • Nuclear Pore / metabolism*
  • Nuclear Pore Complex Proteins*
  • Nuclear Proteins / chemistry

Substances

  • Nuclear Pore Complex Proteins
  • Nuclear Proteins