Abstract
In the present paper we study expression of alpha-6 integrin in normal paraepidermal epithelium, in CIN and in cervical invasive carcinoma HPV 16/18 positive and negative. The results suggest that alpha-6 integrin might be a marker for the evaluation of malignancy of squamous cell carcinoma. There is no correlation between the expression of alpha-6 integrin and the presence of HPV.
MeSH terms
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Antigens, CD / analysis*
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Biomarkers, Tumor / analysis*
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Carcinoma in Situ / chemistry*
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Carcinoma in Situ / pathology
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Carcinoma in Situ / virology
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Carcinoma, Squamous Cell / chemistry*
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / virology
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DNA, Viral / analysis
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DNA-Binding Proteins*
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Epithelium / chemistry
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Female
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Humans
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Immunohistochemistry
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Integrin alpha6
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Oncogene Proteins, Viral / analysis
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Papillomaviridae / isolation & purification*
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Repressor Proteins*
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Uterine Cervical Neoplasms / chemistry*
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Uterine Cervical Neoplasms / pathology
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Uterine Cervical Neoplasms / virology
Substances
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Antigens, CD
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Biomarkers, Tumor
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DNA, Viral
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DNA-Binding Proteins
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E6 protein, Human papillomavirus type 16
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E6 protein, Human papillomavirus type 18
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Integrin alpha6
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Oncogene Proteins, Viral
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Repressor Proteins