Abstract
[reaction: see text] The synthesis of the C(1)-C(12) fragment of fostriecin was achieved from (S)-glycidol in 15 steps by using an enantioselective allytitanation reaction and a ring-closure metathesis as the key steps.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Antibiotics, Antineoplastic / chemical synthesis*
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Antibiotics, Antineoplastic / chemistry
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Cyclization
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Epoxy Compounds / chemical synthesis*
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Epoxy Compounds / chemistry
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Molecular Structure
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Polyenes
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Propanols / chemical synthesis*
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Propanols / chemistry
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Pyrones
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Stereoisomerism
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Structure-Activity Relationship
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Topoisomerase II Inhibitors
Substances
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Alkenes
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Antibiotics, Antineoplastic
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Enzyme Inhibitors
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Epoxy Compounds
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Polyenes
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Propanols
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Pyrones
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Topoisomerase II Inhibitors
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glycidol
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fostriecin