Tricyclic antidepressant overdose: a review

G W Kerr; A C McGuffie; S Wilkie

doi:10.1136/emj.18.4.236

Tricyclic antidepressant overdose: a review

Emerg Med J. 2001 Jul;18(4):236-41. doi: 10.1136/emj.18.4.236.

Authors

G W Kerr¹, A C McGuffie, S Wilkie

Affiliation

¹ Accident and Emergency Department, Ayr Hospital, Dalmellington Road, Ayr, Scotland. gary.kerr@aaaht.scot.nhs.uk

Abstract

Overdoses of tricyclic antidepressants are among the commonest causes of drug poisoning seen in accident and emergency departments. This review discusses the pharmacokinetics, clinical presentation and treatment of tricyclic overdose.

Publication types

Review

MeSH terms

Anti-Arrhythmia Agents / therapeutic use
Antidepressive Agents, Tricyclic / pharmacokinetics
Antidepressive Agents, Tricyclic / poisoning*
Cardiovascular Diseases / chemically induced
Cardiovascular Diseases / prevention & control
Drug Overdose / complications
Drug Overdose / diagnosis
Drug Overdose / therapy
Humans
Inactivation, Metabolic*
Sodium Bicarbonate / therapeutic use
Sorption Detoxification / methods

Substances

Anti-Arrhythmia Agents
Antidepressive Agents, Tricyclic
Sodium Bicarbonate