Abstract
From a defatted chloroform extract of the aerial parts of Hypoestes serpens a new diterpene exhibiting relaxant activity on isolated rat aorta was obtained. The structure of this compound, named serpendione (1), was fully established by the interpretation of its spectral data.
MeSH terms
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Animals
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Aorta / drug effects
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Chloroform
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Cyclooctanes*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Models, Chemical
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Muscle Relaxation / drug effects*
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Rats
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Spectrophotometry, Infrared
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Vasodilation / drug effects*
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Vasodilator Agents / isolation & purification*
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Vasodilator Agents / pharmacology
Substances
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Cyclooctanes
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Diterpenes
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Vasodilator Agents
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serpendione
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Chloroform