Abstract
To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines
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Amino Acid Sequence
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Female
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Genes, Viral*
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Genes, vif / genetics
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Genes, vpr / genetics
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Genes, vpu / genetics
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Genetic Variation
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HIV Infections / prevention & control
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HIV Infections / virology*
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HIV-1 / classification
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HIV-1 / genetics*
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Humans
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Male
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Molecular Sequence Data
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Phylogeny
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Sequence Alignment
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South Africa
Associated data
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GENBANK/AF004885
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GENBANK/AF005496
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GENBANK/AF067154
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GENBANK/AF067155
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GENBANK/AF067157
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GENBANK/AF067158
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GENBANK/AF075703
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GENBANK/AF077336
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GENBANK/AF082395
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GENBANK/AF084936
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GENBANK/AF110965
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GENBANK/AF110967
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GENBANK/AF110972
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GENBANK/AF110977
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GENBANK/AF110980
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GENBANK/AF190127
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GENBANK/AF325742
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GENBANK/AF325743
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GENBANK/AF325744
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GENBANK/AF325745
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GENBANK/AF325746
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GENBANK/AF325747
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GENBANK/AF325748
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GENBANK/AF325749
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GENBANK/AF325750
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GENBANK/AF325751
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GENBANK/AF325752
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GENBANK/AF325753
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GENBANK/AF325754
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GENBANK/AF325755
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GENBANK/AF325756
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GENBANK/AF325757
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GENBANK/AF325758
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GENBANK/AF325759
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GENBANK/AF325760
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GENBANK/AF325761
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GENBANK/AF325762
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GENBANK/AF325763
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GENBANK/L20587