Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs

V K Khavinson; V V Yuzhakov; I M Kvetnoi; V V Malinin; V V Popuchiev; N K Fomina

doi:10.1023/a:1017676104877

Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs

Bull Exp Biol Med. 2001 Mar;131(3):285-92. doi: 10.1023/a:1017676104877.

Authors

V K Khavinson¹, V V Yuzhakov, I M Kvetnoi, V V Malinin, V V Popuchiev, N K Fomina

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Russian Academy of Medical Sciences, Obninsk.

PMID: 11427924
DOI: 10.1023/a:1017676104877

Abstract

Studies of the effects of vilon and epithalon on functional morphology of the thymus, spleen, and duodenum in intact rats and rats exposed to single whole-body gamma-irradiation in a dose of 6 Gy showed that vilon stimulated proliferative activity of thymocytes and enhanced proliferative potential of stem cells in the intestine, thus stimulating the postradiation recovery of critical organs. Epithalon decelerated metabolic processes in the duodenal mucosa and suppressed hemopoiesis and lymphopoiesis in the spleen.

MeSH terms

Animals
Biological Factors / pharmacology*
Cell Division
Dipeptides / pharmacology*
Duodenum / cytology
Duodenum / metabolism
Duodenum / physiology
Duodenum / radiation effects*
Gamma Rays
Immunohistochemistry
Male
Oligopeptides / pharmacology*
Proliferating Cell Nuclear Antigen / metabolism
Radiation Tolerance*
Rats
Rats, Wistar
Spleen / cytology
Spleen / metabolism
Spleen / physiology
Spleen / radiation effects*
Stem Cells / cytology
Stem Cells / radiation effects
Thymus Gland / cytology
Thymus Gland / metabolism
Thymus Gland / physiology
Thymus Gland / radiation effects*

Substances

Biological Factors
Dipeptides
Oligopeptides
Proliferating Cell Nuclear Antigen
lysylglutamic acid
alanyl-glutamyl-aspartyl-glycine