Regulatory effects of Ribotim on functional activity of neutrophils and wound healing during experimental burn trauma

S V Semochkin; E M Bekman; O A Baranova; V Y Arion

doi:10.1023/a:1017655600334

Regulatory effects of Ribotim on functional activity of neutrophils and wound healing during experimental burn trauma

Bull Exp Biol Med. 2001 Mar;131(3):257-9. doi: 10.1023/a:1017655600334.

Authors

S V Semochkin¹, E M Bekman, O A Baranova, V Y Arion

Affiliation

¹ Laboratory of Molecular Immunology, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow.

PMID: 11427914
DOI: 10.1023/a:1017655600334

Abstract

We studied the effects of ribonucleic immunotropic preparation Ribotim obtained from the thymus on functional activity of peripheral blood neutrophils and wound healing after burn trauma. Immunotherapy normalized immunological parameters, attenuated demarcation inflammation in burn wound, and promoted epithelialization of the wound surface preserving skin structures.

MeSH terms

Adjuvants, Immunologic / pharmacology*
Adjuvants, Immunologic / therapeutic use
Animals
Burns / drug therapy
Burns / physiopathology*
Male
Neutrophils / cytology
Neutrophils / drug effects*
RNA / pharmacology*
RNA / therapeutic use
Rats
Rats, Wistar
Thymus Gland / chemistry
Tissue Extracts / pharmacology*
Tissue Extracts / therapeutic use
Wound Healing / drug effects*

Substances

Adjuvants, Immunologic
Tissue Extracts
RNA