Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C

FASEB J. 2001 Jul;15(9):1583-5. doi: 10.1096/fj.00-0787fje.
No abstract available

MeSH terms

  • Antimetabolites, Antineoplastic / pharmacology*
  • Apoptosis
  • Cytarabine / pharmacology*
  • DNA / biosynthesis
  • DNA / drug effects
  • Enzyme Activation / drug effects
  • HL-60 Cells
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases / metabolism
  • Oxidative Stress / physiology
  • Reactive Oxygen Species / metabolism
  • Signal Transduction
  • Sphingomyelin Phosphodiesterase / metabolism*
  • U937 Cells
  • src-Family Kinases / metabolism*

Substances

  • Antimetabolites, Antineoplastic
  • Reactive Oxygen Species
  • Cytarabine
  • DNA
  • lyn protein-tyrosine kinase
  • src-Family Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases
  • Sphingomyelin Phosphodiesterase