Narcolepsy and other non-SAS hypersomnia in sleep breathing disorders clinic

Psychiatry Clin Neurosci. 2001 Jun;55(3):203-4. doi: 10.1046/j.1440-1819.2001.00826.x.

Abstract

Four of the 708 snorers (0.56%), referred to our sleep breathing disorders clinic for the past 2 years were diagnosed as having narcolepsy-cataplexy. Detecting HLA DRB1*1501/DQB1*0602 positive was informative for differentiating genuine narcolepsy from non-sleep apnea syndrome (non-SAS) hypersomnia in our clinic. A non-SAS obese boy, diagnosed as having essential hypersomnia syndrome, was found to be HLA DRB1*1502/DQB1*0601 positive. His hypocretin concentration was 206 pg/mL in the cerebrospinal fluid.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Ambulatory Care Facilities
  • Carrier Proteins / cerebrospinal fluid
  • Disorders of Excessive Somnolence / complications*
  • Disorders of Excessive Somnolence / epidemiology*
  • Disorders of Excessive Somnolence / immunology
  • Female
  • HLA-DQ Antigens / immunology
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / immunology
  • HLA-DRB1 Chains
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Middle Aged
  • Narcolepsy / complications*
  • Narcolepsy / epidemiology*
  • Narcolepsy / immunology
  • Neuropeptides / cerebrospinal fluid
  • Orexins
  • Sleep Apnea Syndromes / complications*

Substances

  • Carrier Proteins
  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins