Biology of kidney cells can be used as a model for further understanding of ontogeny-recapitulating phylogeny. The common and species-specific structural and functional relationship between blood capillaries and the environment via a filtration barrier of nephrons is a biological phenomenon resulting from renal cell memory acquired through evolution. Genetically programmed development, a subsequent series of gene expression, and inductive interactions played a key role in differentiation and maintenance of specific activities of kidneys in birds and mammals. Various environmental factors may alter kidney development and specific activities at the levels of gene expression, repression, or derepression, and defensive mechanisms involved in reaction to risk factors are developed. Autoimmunity and cancerogenesis are closely dependent on a variety of environmental agents, such as antigens originating from infections with some viruses and toxins, or irradiation, advanced industrialization, and progress of civilization. As a result of gene mutation, delation, rearrangement, and/or susceptibility to different agents, renal cell memory is altered. Instead of cell-specific activities, the abilities for regeneration, and other genetically programmed activities, the genesis of kidney diseases are common. Balkan endemic nephropathy, as regional disease, is an important example of the role, of environmental agents, at the level of genes. Research programs on molecular genetics will contribute to our efforts both to prevent infections and to elucidate the genesis, diagnosis, prognosis, prevention, and therapy of kidney diseases.