Efficient scavenging of Ph3P and Ph3P=O with high-loading merrifield resin

B H Lipshutz; P A Blomgren

doi:10.1021/ol0159219

Efficient scavenging of Ph3P and Ph3P=O with high-loading merrifield resin

Org Lett. 2001 Jun 14;3(12):1869-71. doi: 10.1021/ol0159219.

Authors

B H Lipshutz¹, P A Blomgren

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu

PMID: 11405732
DOI: 10.1021/ol0159219

Abstract

[see reaction]. A simple, highly effective method for removing triphenylphosphine and/or triphenylphosphine oxide from reaction mixtures is described. Commercially available high-loading chloromethylated polystyrene 1, modified in situ with NaI, acts as a scavenger resin. Several coupling reactions catalyzed by Pd(0) or Ni(0) which require the removal of triphenylphosphine are tested.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Catalysis
Nickel / chemistry
Organophosphorus Compounds / chemistry*
Palladium / chemistry
Resins, Plant
Sodium Iodide / chemistry

Substances

Organophosphorus Compounds
Resins, Plant
triphenylphosphine
Palladium
Nickel
Sodium Iodide
triphenylphosphine oxide

Grants and funding

GM 40287/GM/NIGMS NIH HHS/United States