Abstract
Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b] [1,3,4] thiadiazolones/thiadiazinones 4-15 and the related compounds 16-21 have been synthesized from treatment of 4-amino-3-mercapto-6-substituted-1,2,4-triazin-5-ones 1 with bifunctional oxygen and halogen compounds via heterocyclization reactions. Structures of the products have been deduced from their elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of the series, compounds 1e, 4e, 4f, 5, 6 and 16 showing a significant activity in Leukemia, Lung, Breast and CNS anticancer evaluation.
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology*
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Quantitative Structure-Activity Relationship
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Triazines / chemical synthesis*
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Triazines / pharmacology*
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Tumor Cells, Cultured
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Heterocyclic Compounds
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Triazines