Potentiation of antitumor effects of cisplatin by tumor necrosis factor-beta

G M Sysoeva; V A Fadina; N A Popova; E V Nikitenko; V P Nikolin; S I Il'nitskaya; V I Kaledin

doi:10.1023/a:1017548113421

Potentiation of antitumor effects of cisplatin by tumor necrosis factor-beta

Bull Exp Biol Med. 2001 Feb;131(2):159-61. doi: 10.1023/a:1017548113421.

Authors

G M Sysoeva¹, V A Fadina, N A Popova, E V Nikitenko, V P Nikolin, S I Il'nitskaya, V I Kaledin

Affiliation

¹ Research Construction-and-Technology Institute of Biologically Active Substances, Vektor State Research Center, Novosibirsk, Siberia, Russia. nb@online.sinor.ru

PMID: 11391402
DOI: 10.1023/a:1017548113421

Abstract

Recombinant tumor necrosis factor-beta potentiated the inhibitory effect of cisplatin on intramuscularly transplanted GA-1 tumor and liver metastasis in mice. The antitumor effect was related to cytotoxic and cytostatic activities of the test preparations rather than to initiation of apoptosis.

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Apoptosis
Cisplatin / therapeutic use*
Drug Synergism
Liver Neoplasms / drug therapy*
Liver Neoplasms / secondary
Lymphotoxin-alpha / therapeutic use*
Macrophages, Peritoneal / drug effects
Macrophages, Peritoneal / immunology
Male
Mice
Mice, Inbred A
Mitosis
Muscle Neoplasms / chemically induced
Muscle Neoplasms / drug therapy*
Muscle Neoplasms / pathology
Neoplasm Transplantation
Neutrophils / drug effects
Neutrophils / metabolism
Peroxides / metabolism
Phagocytosis / drug effects
Reactive Oxygen Species / metabolism

Substances

Antineoplastic Agents
Lymphotoxin-alpha
Peroxides
Reactive Oxygen Species
Cisplatin