Transgenic and gene "knockout" models in alcohol research

Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):60S-66S. doi: 10.1097/00000374-200105051-00011.

Abstract

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Paula L. Hoffman and Takeshi Yagi. The presentations were (1) cAMP signaling in ethanol sensitivity and tolerance, by Boris Tabakoff; (2) Synaptic signaling pathways of Fyn-tyrosine kinase, by Takeshi Yagi; (3) Ethanol drinking and sensitization in dopaminergic and serotonergic receptor knockouts, by Tamara J. Phillips; (4) ICAM-1 is involved in early alcohol-induced liver injury in the mouse given enteral alcohol, by Hiroshi Kono; and (5) Strategies for targeted and regulated knockouts, by Robert O. Messing and Doo-Sup Choi.

Publication types

  • Review

MeSH terms

  • Adenylyl Cyclases / genetics
  • Adenylyl Cyclases / metabolism
  • Alcohol Drinking / genetics*
  • Alcohol Drinking / metabolism
  • Animals
  • Central Nervous System Depressants / pharmacology
  • Cyclic AMP / genetics*
  • Cyclic AMP / metabolism
  • Ethanol / pharmacology
  • Intercellular Adhesion Molecule-1 / genetics
  • Intercellular Adhesion Molecule-1 / metabolism
  • Liver Diseases, Alcoholic / genetics*
  • Liver Diseases, Alcoholic / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout / genetics*
  • Mice, Knockout / metabolism
  • Mice, Transgenic / genetics*
  • Mice, Transgenic / metabolism
  • Models, Animal
  • Proto-Oncogene Proteins / deficiency
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-fyn
  • Receptors, Dopamine / deficiency
  • Receptors, Dopamine / genetics
  • Receptors, Serotonin / deficiency
  • Receptors, Serotonin / genetics
  • Signal Transduction / drug effects
  • Signal Transduction / genetics

Substances

  • Central Nervous System Depressants
  • Proto-Oncogene Proteins
  • Receptors, Dopamine
  • Receptors, Serotonin
  • Intercellular Adhesion Molecule-1
  • Ethanol
  • Cyclic AMP
  • Fyn protein, mouse
  • Proto-Oncogene Proteins c-fyn
  • Adenylyl Cyclases