Abstract
The most prevalent macrolide resistance phenotype and genotype among pneumococcal isolates was the cMLSB phenotype [erm(B) or erm(B)/mef(A)] (91.3%). We studied the distribution of other resistance genes, tet(M), catpC194, aph3'-III, in these strains, seeing evolution at work in that some strains carried different combinations of resistance determinants. The most prevalent patterns associated with resistance to erythromycin [erm(B)] were resistance to tetracycline [tet(M)] and chloramphenicol (catpC194) (48.2%) or resistance to tetracycline [tet(M)] alone (42.2%). In our isolates of Streptococcus pneumoniae there was a strong association of the erm(B) and tet(M) genes with Tn1545-related elements.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Chloramphenicol Resistance / genetics
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Conjugation, Genetic / genetics
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DNA Transposable Elements / genetics*
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Drug Resistance, Microbial / genetics
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Humans
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Integrases / genetics*
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Kanamycin Kinase / genetics*
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Macrolides
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Membrane Proteins / metabolism
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Methyltransferases / metabolism
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Microbial Sensitivity Tests
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Spain
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / enzymology
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Streptococcus pneumoniae / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA Transposable Elements
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Macrolides
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MefA protein, Streptococcus
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Membrane Proteins
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Tet M resistance protein, Bacteria
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Methyltransferases
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rRNA (adenosine-O-2'-)methyltransferase
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Kanamycin Kinase
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Integrases