Abstract
[reaction: see text] Carbocyclic L-2'deoxynucleosides 17 were synthesized on solid phase in four steps from the appropriately protected intermedate 11. The Mitsunobu reaction was used as a condensation method between the carbocyclic moiety and heterocyclic bases. The regioselectivity of the carbocyclic nucleosides was compared between the solid and solution phase syntheses.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alanine / analogs & derivatives
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Alanine / isolation & purification*
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Alanine / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antiviral Agents / chemical synthesis
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Combinatorial Chemistry Techniques / methods*
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Nucleosides / chemical synthesis*
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Solvents / pharmacology
Substances
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Antineoplastic Agents
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Antiviral Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Nucleosides
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Solvents
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neodysiherbaine A
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Alanine