Homologous recombination: from model organisms to human disease

Genome Biol. 2001;2(5):REVIEWS1014. doi: 10.1186/gb-2001-2-5-reviews1014. Epub 2001 Apr 26.

Abstract

Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • BRCA1 Protein / physiology
  • BRCA2 Protein
  • DNA Damage
  • DNA Helicases / physiology
  • DNA-Binding Proteins / physiology
  • Humans
  • Models, Genetic
  • Neoplasm Proteins / physiology
  • Neoplasms / genetics
  • Rad51 Recombinase
  • Recombination, Genetic*
  • Transcription Factors / physiology

Substances

  • BRCA1 Protein
  • BRCA2 Protein
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Transcription Factors
  • RAD51 protein, human
  • Rad51 Recombinase
  • DNA Helicases