Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels

Vet Hum Toxicol. 2001 Jun;43(3):174-5.

Abstract

A 54-y-old man ingested 2 g of bulk laboratory diazepam and was treated with activated charcoal, enhanced diuresis and flumazenil infusion. The treatment resulted in awakening, but the patient had drowsiness, dysarthria, diplopia, and dizziness for 9 d. Blood levels of diazepam and its main metabolite, nordiazepam, were obtained for 1 mo. The half-lives in this benzodiazepine overdose were longer than those seen with therapeutic doses. Benzodiazepines should not be readministrated when patients awake after suicide attempts.

Publication types

  • Case Reports

MeSH terms

  • Anti-Anxiety Agents / pharmacokinetics
  • Anti-Anxiety Agents / poisoning*
  • Chromatography, High Pressure Liquid
  • Diazepam / pharmacokinetics
  • Diazepam / poisoning*
  • Flumazenil / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Nordazepam* / blood
  • Poisoning / drug therapy
  • Poisoning / metabolism*
  • Suicide, Attempted*
  • Treatment Outcome

Substances

  • Anti-Anxiety Agents
  • Flumazenil
  • Nordazepam
  • Diazepam