PPAR gamma: an essential role in metabolic control

Nutr Metab Cardiovasc Dis. 2001 Feb;11(1):64-9.

Abstract

The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Arteriosclerosis / etiology
  • Gene Expression
  • Humans
  • Inflammation / etiology
  • Insulin / physiology*
  • Ligands
  • Prostaglandin D2 / analogs & derivatives*
  • Prostaglandin D2 / analysis
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Thiazoles
  • Thiazolidinediones*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*

Substances

  • Insulin
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Thiazoles
  • Thiazolidinediones
  • Transcription Factors
  • 9-deoxy-delta-9-prostaglandin D2
  • 2,4-thiazolidinedione
  • Prostaglandin D2