Abstract
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipose Tissue / metabolism*
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Animals
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Arteriosclerosis / etiology
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Gene Expression
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Humans
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Inflammation / etiology
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Insulin / physiology*
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Ligands
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Prostaglandin D2 / analogs & derivatives*
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Prostaglandin D2 / analysis
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism
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Receptors, Cytoplasmic and Nuclear / physiology*
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Thiazoles
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Thiazolidinediones*
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription Factors / physiology*
Substances
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Insulin
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Thiazoles
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Thiazolidinediones
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Transcription Factors
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9-deoxy-delta-9-prostaglandin D2
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2,4-thiazolidinedione
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Prostaglandin D2