Distribution of various calcium channel alpha(1) subunits in murine DRG neurons and antinociceptive effect of omega-conotoxin SVIB in mice

M Murakami; T Suzuki; O Nakagawasai; H Murakami; S Murakami; A Esashi; R Taniguchi; T Yanagisawa; K Tan-No; I Miyoshi; H Sasano; T Tadano

doi:10.1016/s0006-8993(01)02427-1

Distribution of various calcium channel alpha(1) subunits in murine DRG neurons and antinociceptive effect of omega-conotoxin SVIB in mice

Brain Res. 2001 Jun 8;903(1-2):231-6. doi: 10.1016/s0006-8993(01)02427-1.

Authors

M Murakami¹, T Suzuki, O Nakagawasai, H Murakami, S Murakami, A Esashi, R Taniguchi, T Yanagisawa, K Tan-No, I Miyoshi, H Sasano, T Tadano

Affiliation

¹ Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryoumachi, Aoba-ku, Sendai 980-8575, Japan. mmura@mail.cc.tohoku.ac.jp

PMID: 11382408
DOI: 10.1016/s0006-8993(01)02427-1

Abstract

Immunohistological study revealed the differential localization of subtypes of voltage-dependent calcium channels in the dorsal root ganglion neurons. Intrathecal injection of omega-conotoxin SVIB, an analogue of omega-conotoxin GVIA, which acts on N-type voltage-dependent calcium channels, significantly shortened the licking time in the late phase of a formalin test.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Behavior, Animal / drug effects
Calcium Channel Blockers / pharmacology*
Calcium Channels, N-Type / analysis*
Calcium Channels, N-Type / physiology
Ganglia, Spinal / chemistry*
Ganglia, Spinal / cytology
Injections, Spinal
Mice
Neurons / chemistry*
Neurons / drug effects
Nociceptors / drug effects*
Pain Measurement / drug effects
omega-Conotoxins / pharmacology*

Substances

Calcium Channel Blockers
Calcium Channels, N-Type
omega-Conotoxins
omega-conotoxin SVIB