Abstract
The protein network protecting the stability of the genome is defective in Fanconi anemia (FA). The newest in a series of FA proteins is involved in DNA damage response, but the mechanism is still unclear. Clues may come from yeast two-hybrid experiments, an extraordinarily successful tool for determining molecular function.
MeSH terms
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Animals
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Cell Cycle Proteins*
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DNA Damage
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DNA-Binding Proteins*
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Fanconi Anemia / genetics*
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Fanconi Anemia / metabolism*
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Fanconi Anemia / pathology
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Fanconi Anemia Complementation Group A Protein
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Fanconi Anemia Complementation Group D2 Protein
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Fanconi Anemia Complementation Group Proteins
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Phenotype
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Proteins / genetics
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Proteins / metabolism
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Two-Hybrid System Techniques
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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FANCA protein, human
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FANCD2 protein, human
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Fanconi Anemia Complementation Group A Protein
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Fanconi Anemia Complementation Group D2 Protein
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Fanconi Anemia Complementation Group Proteins
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Nuclear Proteins
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Proteins