Synthesis and hydrolytic stability studies of albendazole carrier prodrugs

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1359-62. doi: 10.1016/s0960-894x(01)00214-1.

Abstract

Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albendazole / chemical synthesis*
  • Albendazole / chemistry
  • Albendazole / pharmacology
  • Anthelmintics / chemical synthesis*
  • Anthelmintics / chemistry
  • Anthelmintics / pharmacology
  • Drug Stability
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry
  • Prodrugs / pharmacology
  • Solubility
  • Water / chemistry

Substances

  • Anthelmintics
  • Prodrugs
  • Water
  • Albendazole