Isolation and structures of hedaols A, B, and C, new bisnorditerpenes from a Japanese brown alga

N Takada; R Watanabe; K Suenaga; K Yamada; D Uemura

doi:10.1021/np0005661

Isolation and structures of hedaols A, B, and C, new bisnorditerpenes from a Japanese brown alga

J Nat Prod. 2001 May;64(5):653-5. doi: 10.1021/np0005661.

Authors

N Takada¹, R Watanabe, K Suenaga, K Yamada, D Uemura

Affiliation

¹ Department of Chemistry, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

PMID: 11374968
DOI: 10.1021/np0005661

Abstract

New bisnorditerpenes, hedaols A (1), B (2), and C (3), were isolated from the Japanese brown alga Sargassum sp. Their structures were determined by spectroscopic analysis. The absolute stereocenter of 1 was determined by the modified Mosher's method. Hedaols showed low cytotoxicity against P388 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Humans
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Phaeophyceae / chemistry*
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Diterpenes
hedaol A
hedaol B
hedaol C