Two new fatty diterpenoids from Salvia miltiorrhiza

J Nat Prod. 2001 May;64(5):648-50. doi: 10.1021/np000345v.

Abstract

Two new fatty abietane diterpenoids, oleoyl neocryptotanshinone (1) and oleoyl danshenxinkun A (2), were isolated as minor components from the roots of Salvia miltiorrhiza. Their structures were established on the basis of spectral evidence. In preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid.

MeSH terms

  • Animals
  • China
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Hydrolysis
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Oleic Acids / chemistry*
  • Oleic Acids / isolation & purification
  • Oleic Acids / pharmacology
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology
  • Rabbits
  • Spectrophotometry, Ultraviolet

Substances

  • Diterpenes
  • Oleic Acids
  • Platelet Aggregation Inhibitors
  • oleoyl danshenxinkun A
  • oleoyl neocryptotanshinone