We present a case of Idiopathic Portal Hypertension (IPH) with Splenic infarct in a 23-year-old female. She was referred to the hospital because of enlargement of liver and spleen. A computed axial tomography revealed Splenic infarct. The spleen was surgically removed. At laparotomy the liver was found to be enlarged and a liver biopsy performed. The biopsy showed characteristic changes of IPH. After the splenic resection all hematologic manifestations disappeared, suggesting that they were due to hypersplenism. The IPH is very uncommon in western countries. We don't know of any case previously reported in Argentina and our patient is the first case of IPH with Splenic infarct.