Synthesis of imidazo[1,2-a]pyridine derivatives as antiviral agents

Arzneimittelforschung. 2001;51(4):304-9. doi: 10.1055/s-0031-1300042.

Abstract

The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Giant Cells / drug effects
  • Giant Cells / virology
  • HIV-1 / drug effects
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology*
  • Quantitative Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Imidazoles
  • Pyridines