Abstract
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Giant Cells / drug effects
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Giant Cells / virology
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HIV-1 / drug effects
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Pyridines / chemical synthesis*
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Pyridines / pharmacology*
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Quantitative Structure-Activity Relationship
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Antiviral Agents
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Imidazoles
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Pyridines