Objective: A comparative study was carried out on the effect of two kinds of male contraceptive drugs, gossypol and the abstract of tripterygium wilfordii T7, on the human spermatozoa ATPase activity.
Methods: The specific activity of total ATPase and Na-K ATPase of spermatozoa was assayed in this experiment.
Results: (1) The effect of gossypol on the human spermatozoa ATPase activity is inhibitory and concentration-dependent; and (2) The abstract of tripterygium wilfodii T7 has no effect on the human spermatozoa ATPase activity.
Conclusions: The antifertility effects of gossypol and T7 are different.