Objective: To investigate the effect of Purified Xuefu Capsule (PXC) on cardiac haemodynamic and oxygen consumption in acute myocardial ischemia of experimental dogs.
Methods: The coronary arteries was ligated to create the myocardial ischemic modle and gave them PXC through the duodenum. The effect of PXC on the systolic and diastolic function, volume of blood flow in coronary arteries and cardiac output of acute ischemic heart of experimental dogs were examined.
Results: After ligation of the coronary artery the myocardial ischemia was formed, the systolic and diastolic function, volume of blood flow in coronary arteries and cardiac output were decreased significantly in the control group, whereas these indexes in high-dose and low-dose PXC group were improved to some extent, the effect of high-dose PXC group was better than that of the low-dose PXC group. Furthermore high-dose PXC could reduce the oxygen consumption.
Conclusions: PXC could prevent the cardiac pump function from acute myocardial ischemia of experimental dogs. The mechanism may be related to reduce the oxygen consumption and increase the blood supplement to myocardium.