Differential cell death response to photodynamic therapy is dependent on dose and cell type

L Wyld; M W Reed; N J Brown

doi:10.1054/bjoc.2001.1795

Differential cell death response to photodynamic therapy is dependent on dose and cell type

Br J Cancer. 2001 May 18;84(10):1384-6. doi: 10.1054/bjoc.2001.1795.

Authors

L Wyld¹, M W Reed, N J Brown

Affiliation

¹ Section of Surgical and Anaesthetic Sciences, Division of Clinical Sciences, University of Sheffield, Floor K, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

Abstract

PDT-induced cell death, by either apoptosis or necrosis may vary with cell type or PDT dose. 5 cell types were treated with varying doses of aminolaevulinic acid-induced PDT and the type of cell death analysed. The mode of cell death was found to depend on both cell type and light dose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / drug effects
Breast Neoplasms
Carcinoma 256, Walker
Cell Death / drug effects*
Cells, Cultured
Dose-Response Relationship, Drug
Endothelium, Vascular / cytology*
Endothelium, Vascular / drug effects
Endothelium, Vascular / radiation effects
Female
Genes, p53
Humans
Photochemotherapy*
Rats
Tumor Cells, Cultured
Urinary Bladder Neoplasms