Abstract
A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemical synthesis
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Antioxidants / pharmacology
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Catechols / chemical synthesis*
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Catechols / pharmacology*
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Cell Line
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Culture Media
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Humans
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L-Lactate Dehydrogenase / metabolism
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NAD / metabolism
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Pyrazines / chemical synthesis*
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Pyrazines / pharmacology*
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Radiation-Protective Agents / chemical synthesis*
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Radiation-Protective Agents / pharmacology*
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Ultraviolet Rays
Substances
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Antioxidants
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Catechols
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Culture Media
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Pyrazines
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Radiation-Protective Agents
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NAD
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2-aminopyrazine
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L-Lactate Dehydrogenase