Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality

Bioorg Med Chem. 2001 Apr;9(4):1037-44. doi: 10.1016/s0968-0896(00)00321-7.

Abstract

A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis
  • Antioxidants / pharmacology
  • Catechols / chemical synthesis*
  • Catechols / pharmacology*
  • Cell Line
  • Culture Media
  • Humans
  • L-Lactate Dehydrogenase / metabolism
  • NAD / metabolism
  • Pyrazines / chemical synthesis*
  • Pyrazines / pharmacology*
  • Radiation-Protective Agents / chemical synthesis*
  • Radiation-Protective Agents / pharmacology*
  • Ultraviolet Rays

Substances

  • Antioxidants
  • Catechols
  • Culture Media
  • Pyrazines
  • Radiation-Protective Agents
  • NAD
  • 2-aminopyrazine
  • L-Lactate Dehydrogenase