NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines

Bioorg Med Chem Lett. 2001 May 7;11(9):1189-91. doi: 10.1016/s0960-894x(01)00171-8.

Abstract

I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases.

MeSH terms

  • Acetylcysteine / analogs & derivatives
  • Acetylcysteine / chemical synthesis*
  • Acetylcysteine / pharmacology*
  • Antioxidants / chemical synthesis*
  • Antioxidants / pharmacology*
  • Astrocytes / drug effects
  • Astrocytes / metabolism
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / metabolism
  • Cell Line
  • Cysteamine / analogs & derivatives
  • Cysteamine / chemical synthesis*
  • Cysteamine / pharmacology*
  • Glutathione / metabolism*
  • HIV Infections / metabolism
  • Humans
  • Indicators and Reagents
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Prodrugs / chemical synthesis*
  • Prodrugs / pharmacology*

Substances

  • Antioxidants
  • I-152 compound
  • Indicators and Reagents
  • Prodrugs
  • Cysteamine
  • Glutathione
  • Acetylcysteine