Abstract
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / growth & development
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Bacteria / ultrastructure
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Cell Wall / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Combinatorial Chemistry Techniques
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Hydrazines / chemical synthesis*
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Hydrazines / pharmacology*
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Mass Spectrometry
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Microbial Sensitivity Tests
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Urea / analogs & derivatives*
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Urea / chemistry*
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Urea / pharmacology*
Substances
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Anti-Bacterial Agents
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Hydrazines
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hydrazine
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Urea