Pre-emptive analgesia with local anaesthetic for herniorrhaphy

Anaesthesia. 2001 May;56(5):414-7. doi: 10.1046/j.1365-2044.2001.01621.x.

Abstract

There is little evidence that local anaesthetics produce pre-emptive analgesia and one reason may be the short duration of action of the drugs studied. We examined the pre-emptive analgesic effect of a bupivacaine field block on postoperative pain in 40 patients following herniorrhaphy in a double-blind, randomised trial. Patients received the block either after induction but before surgery, or after surgery but before the end of anaesthesia. There was no difference in pain scores or analgesic consumption up to 7 days after surgery between the two groups. We have demonstrated that bupivacaine does not appear to provide significant pre-emptive analgesia following a field block for herniorrhaphy. This study does not support the hypothesis that pre-emptive analgesia with local anaesthetic depends upon the duration of action of the drug.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Anesthesia, General
  • Anesthetics, Local / administration & dosage*
  • Bupivacaine / administration & dosage*
  • Double-Blind Method
  • Hernia, Inguinal / surgery*
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Pain, Postoperative / etiology
  • Pain, Postoperative / prevention & control*
  • Statistics, Nonparametric
  • Treatment Outcome

Substances

  • Anesthetics, Local
  • Bupivacaine