Highly regioselective Friedländer reaction

Org Lett. 2001 Apr 19;3(8):1101-3. doi: 10.1021/ol006785v.

Abstract

[reaction: see text]. A highly regioselective Friedländer reaction is described. By introduction of a phosphonate group at one of the alpha-carbons of a ketone, regioselectivity can be perfectly controlled.

MeSH terms

  • Carbon / chemistry
  • Ketones / chemistry
  • Magnetic Resonance Spectroscopy
  • Methanol / chemistry
  • Models, Chemical
  • Naphthyridines / chemical synthesis*
  • Phosphates / chemistry

Substances

  • Ketones
  • Naphthyridines
  • Phosphates
  • Carbon
  • Methanol