Metabotropic glutamate receptors: structure and new subtype-selective ligands

Farmaco. 2001 Jan-Feb;56(1-2):91-4. doi: 10.1016/s0014-827x(01)01006-0.

Abstract

Metabotropic glutamate receptors (mGluRs) constitute an attractive target for the development of potential neuroprotective agents. Recent advances in the elucidation of the peculiar molecular architecture of mGluRs and in the design and synthesis of subtype selective ligands are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neuroprotective Agents / pharmacology*
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Receptors, Metabotropic Glutamate / chemistry

Substances

  • Neuroprotective Agents
  • Receptors, Metabotropic Glutamate