No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients

A L Nishimura; J R Oliveira; P A Otto; S R Matioli; P R Brito-Marques; V S Bahia; R Nitrini; M Zatz

doi:10.1007/s007020170076

No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients

J Neural Transm (Vienna). 2001;108(3):305-10. doi: 10.1007/s007020170076.

Authors

A L Nishimura¹, J R Oliveira, P A Otto, S R Matioli, P R Brito-Marques, V S Bahia, R Nitrini, M Zatz

Affiliation

¹ Center of the Study of the Human Genome, Department of Biology, Institute of Biosciences, University of São Paulo, Brazil.

PMID: 11341482
DOI: 10.1007/s007020170076

Abstract

In a genome survey for Alzheimer's disease (AD), Zubenko et al. (1998) reported that the 234bp allele of the D10S1423 locus was more frequent among AD cases than in controls. We have analyzed this polymorphic locus in patients and healthy controls and observed that the 226bp allele is the most frequent allele in the D10S1423 locus in Brazilian AD patients. However, no statistically significant association between any D10S1423 allele was observed in AD patients as well as in controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alzheimer Disease / epidemiology
Alzheimer Disease / genetics*
Alzheimer Disease / metabolism
Brazil / epidemiology
Chromosomes, Human, Pair 10 / genetics*
DNA Mutational Analysis
Female
Gene Frequency / genetics*
Genetic Markers / genetics
Genetic Testing
Humans
Male
Middle Aged
Mutation / genetics*
Polymorphism, Genetic / genetics*
Sex Factors

Substances

Genetic Markers