Cervical cancer detection by hybrid capture and evaluation of local risk factors

Int J Gynaecol Obstet. 2001 Apr;73(1):41-6. doi: 10.1016/s0020-7292(00)00390-8.

Abstract

The city of Recife, northeastern Brazil, is reported to have the highest incidence of cervical cancer worldwide (83.2/100000 women).

Objective: To evaluate the efficacy of Hybrid Capture I (HC I) in cervical cancer detection and some risk factors in Recife.

Method: Cervical scrapes for HC I analysis followed by colposcopy were collected from 140 women (70 with cervical cancer and 70 with normal cervix) from three screening services in Recife.

Result: HC I sensitivity and specificity were 82.9 and 41.4%, respectively. The odds ratios for cervical cancer when Gesta > or = 5 and vaginal parity > or = 4 were, respectively, 5.30 and 4.27.

Conclusion: HC I is a moderately sensitive method to detect cervical cancer, but it does not seem to be useful as a primary screening tool for it's low specificity. Early pregnancy, high Gesta/Para and living in rural areas were important local risk factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brazil / epidemiology
  • Case-Control Studies
  • DNA, Viral / isolation & purification
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Middle Aged
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / epidemiology
  • Polymerase Chain Reaction
  • Pregnancy
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / diagnosis*
  • Tumor Virus Infections / epidemiology
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / etiology
  • Uterine Cervical Neoplasms / virology*
  • Viral Load

Substances

  • DNA, Viral