Spatiotemporal maps of brain activity underlying word generation and their modification during repetition priming

J Neurosci. 2001 May 15;21(10):3564-71. doi: 10.1523/JNEUROSCI.21-10-03564.2001.

Abstract

Spatiotemporal maps of brain activity based on magnetoencephalography were used to observe sequential stages in language processing and their modification during repetition priming. Subjects performed word-stem completion and produced either novel or repeated (primed) words across trials. Activation passes from primary visual cortex (activated at approximately 100 msec after word presentation), to left anteroventral occipital ( approximately 180 msec), to cortex in and near Wernicke's ( approximately 210 msec) and then Broca's ( approximately 370 msec) areas. In addition, a posteroventral temporal area is activated simultaneously with posterosuperior temporal cortex. This area shows an early ( approximately 200-245 msec) increase in activation to repeated word stems. In contrast, prefrontal and anterior temporal regions showed activity reductions to repeated word stems late ( approximately 365-500 msec) in processing. These results tend to support classical models of language and suggest that an effect of direct item repetition is to allow word-form processing to increase its contribution to task performance while concurrently allowing reductions in time-consuming frontal temporal processing.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / anatomy & histology
  • Brain / physiology*
  • Brain Mapping*
  • Frontal Lobe / physiology
  • Functional Laterality / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Magnetoencephalography*
  • Male
  • Occipital Lobe / physiology
  • Photic Stimulation
  • Reaction Time / physiology
  • Reference Values
  • Speech / physiology*
  • Temporal Lobe / physiology
  • Verbal Behavior / physiology*
  • Visual Cortex / physiology
  • Word Association Tests