Dimeric L-dopa derivatives as potential prodrugs

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1085-8. doi: 10.1016/s0960-894x(01)00140-8.

Abstract

A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dimerization
  • Drug Stability
  • Half-Life
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Levodopa / analogs & derivatives
  • Levodopa / chemical synthesis*
  • Levodopa / pharmacokinetics*
  • Plasma / metabolism
  • Prodrugs / chemical synthesis*
  • Prodrugs / pharmacokinetics*
  • Rats

Substances

  • Prodrugs
  • Levodopa