Copper(I) chloride: a simple salt for enhancement of polystyrene cationization in matrix-assisted laser desorption/ionization mass spectrometry

S Kéki; G Deák; M Zsuga

doi:10.1002/rcm.284

Copper(I) chloride: a simple salt for enhancement of polystyrene cationization in matrix-assisted laser desorption/ionization mass spectrometry

Rapid Commun Mass Spectrom. 2001;15(9):675-8. doi: 10.1002/rcm.284.

Authors

S Kéki¹, G Deák, M Zsuga

Affiliation

¹ Department of Applied Chemistry, University of Debrecen, H-4010 Debrecen, Hungary.

PMID: 11319788
DOI: 10.1002/rcm.284

Abstract

The possibility of using copper(I) chloride as a doping salt to enhance the cationization of polystyrene in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was investigated. It was shown that copper(I) chloride possesses sufficient solubility in tetrahydrofuran. The parameters of the MALDI mass spectra of different polystyrene samples, such as the number-average (M(n)) and mass-average (M(w)) molecular mass values, obtained by copper(I) cationization were compared with those obtained by means of silver(I) cationization, and good agreement was found. It was also shown that application of copper(I) chloride as a doping salt, and dithranol as a matrix, ensured good MALDI mass spectra of the sample spots even after storage for 1 month.