Abstract
Hormone Replacement Therapy (HRT) represents the first and probably sole therapeutically approach for prevention and treatment of medical postmenopausal disease. Nevertheless, the adverse effects and the risks HRT associated, suggested, to clinical and pharmaceutical research new pharmacological treatment options. Actually a group of compounds, SERMs (Selective Estrogen Receptor Modulators), allows a large interest. These pharmacological agents, due to their estrogen agonist/antagonist properties, are able to bind Estrogen Receptors in female target tissues (bone, brain, heart, etc) with different actions; so, by these properties, SERMs represent actually a possible alternative to HRT.
Publication types
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Comparative Study
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English Abstract
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Review
MeSH terms
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Adult
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Aged
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Animals
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Bone and Bones / drug effects
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Brain / drug effects
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Breast / drug effects
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Breast Neoplasms / chemically induced
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Cardiovascular System / drug effects
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Endometrial Neoplasms / chemically induced
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Female
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Haplorhini
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Hormone Replacement Therapy* / adverse effects
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Humans
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Menopause
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Middle Aged
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Postmenopause
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Raloxifene Hydrochloride / administration & dosage
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Raloxifene Hydrochloride / pharmacology
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Risk Factors
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Selective Estrogen Receptor Modulators* / pharmacology
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Tamoxifen / administration & dosage
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Tamoxifen / pharmacology
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Uterus / drug effects
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Vagina / drug effects
Substances
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Selective Estrogen Receptor Modulators
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Tamoxifen
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Raloxifene Hydrochloride