The objective of this study was to carry out a comparative evaluation of the bond strength to enamel of two present-day fissure sealants, Helioseal and Concise; good adhesion of the material to the tooth surface is one of the requisites for the success of this preventive technique. To this end, 16 caries-free human premolars extracted for orthodontic reasons were used. Proximal, mesial, and distal surfaces were treated and studied. Bond strength was evaluated by the application of compression forces (Instron) at a velocity of 0.5 mm/mm. The overall results obtained do not show significant differences between the two materials.