DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review

Placenta. 2001 Apr:22 Suppl A:S19-23. doi: 10.1053/plac.2001.0674.

Abstract

Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion Molecules*
  • Female
  • HIV Envelope Protein gp120 / metabolism
  • HIV-1 / metabolism*
  • Humans
  • Lectins / metabolism*
  • Lectins, C-Type*
  • Lymph Nodes / metabolism
  • Lymph Nodes / virology
  • Mucous Membrane / metabolism
  • Mucous Membrane / virology
  • Placenta / metabolism*
  • Placenta / virology
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Receptors, Cell Surface / metabolism*
  • Receptors, HIV / metabolism*
  • T-Lymphocytes / metabolism*
  • T-Lymphocytes / virology
  • Viral Proteins / metabolism*

Substances

  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • HIV Envelope Protein gp120
  • Lectins
  • Lectins, C-Type
  • Receptors, Cell Surface
  • Receptors, HIV
  • Viral Proteins