Mechanical unfolding and refolding of proteins: an off-lattice model study

Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Feb;63(2 Pt 1):021905. doi: 10.1103/PhysRevE.63.021905. Epub 2001 Jan 19.

Abstract

Using an off-lattice model, we investigate the response of a protein molecule to external stretching and release. In particular we study the passive force in a protein as a function of the extension of the protein. These force-extension curves exhibit hysteresis loops, whose areas increase with the pulling rate and decrease with thermal noise. Most of these results seem to be appropriately described by a cusp catastrophe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biophysical Phenomena
  • Biophysics
  • Protein Conformation
  • Protein Denaturation
  • Protein Folding
  • Proteins / chemistry*
  • Temperature

Substances

  • Proteins