The association study of DRD2, ACE and AGT gene polymorphisms and metamphetamine dependence

Physiol Res. 2001;50(1):43-50.

Abstract

We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Angiotensinogen / genetics*
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Methamphetamine*
  • Peptidyl-Dipeptidase A / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length*
  • Receptors, Dopamine D2 / genetics*
  • Sex Characteristics
  • Substance-Related Disorders / genetics*

Substances

  • Receptors, Dopamine D2
  • Angiotensinogen
  • Methamphetamine
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases
  • Peptidyl-Dipeptidase A