The library of p-nitrophenyl esters of oligopeptides as a model to study the anticancer drug-peptide conjugates activated during tumor angiogenesis

Acta Pol Pharm. 2000 Nov:57 Suppl:143-6.

Abstract

An indexed library of oligopeptide p-nitrophenyl esters immobilized via methoxy-1,3,5-triazine scaffold on the cellulose support, was synthesized by the step by step procedure and by segment coupling, involving 2-chloro-4,6-dimethoxy-1,3,5-triazine as a condensing reagent. The substrate specificity towards homogenate supernatant of mouse lung cancer LL2 cells has been studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacokinetics
  • Biotransformation
  • Combinatorial Chemistry Techniques
  • Lung Neoplasms / drug therapy
  • Mice
  • Neovascularization, Pathologic / metabolism*
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacokinetics
  • Peptide Library*
  • Triazines / chemical synthesis
  • Triazines / pharmacokinetics

Substances

  • Antineoplastic Agents
  • Oligopeptides
  • Peptide Library
  • Triazines