Abstract
An indexed library of oligopeptide p-nitrophenyl esters immobilized via methoxy-1,3,5-triazine scaffold on the cellulose support, was synthesized by the step by step procedure and by segment coupling, involving 2-chloro-4,6-dimethoxy-1,3,5-triazine as a condensing reagent. The substrate specificity towards homogenate supernatant of mouse lung cancer LL2 cells has been studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacokinetics
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Biotransformation
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Combinatorial Chemistry Techniques
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Lung Neoplasms / drug therapy
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Mice
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Neovascularization, Pathologic / metabolism*
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Oligopeptides / chemical synthesis*
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Oligopeptides / pharmacokinetics
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Peptide Library*
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Triazines / chemical synthesis
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Triazines / pharmacokinetics
Substances
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Antineoplastic Agents
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Oligopeptides
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Peptide Library
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Triazines