Abstract
Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis*
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Alkanes / chemistry
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Alkanes / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Busulfan / chemical synthesis
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Busulfan / chemistry
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Busulfan / pharmacology*
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Cell Division / drug effects
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Inhibitory Concentration 50
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Mesylates / chemical synthesis*
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Mesylates / chemistry
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Mesylates / pharmacology
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Tumor Cells, Cultured
Substances
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2-Tetradecylbutane-1,4-diol dimethanesulphonate
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Alkanes
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Antineoplastic Agents
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Mesylates
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Busulfan