Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues

Bioorg Med Chem Lett. 2001 Mar 26;11(6):861-3. doi: 10.1016/s0960-894x(01)00084-1.

Abstract

Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemical synthesis*
  • Alkanes / chemistry
  • Alkanes / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Busulfan / chemical synthesis
  • Busulfan / chemistry
  • Busulfan / pharmacology*
  • Cell Division / drug effects
  • Inhibitory Concentration 50
  • Mesylates / chemical synthesis*
  • Mesylates / chemistry
  • Mesylates / pharmacology
  • Tumor Cells, Cultured

Substances

  • 2-Tetradecylbutane-1,4-diol dimethanesulphonate
  • Alkanes
  • Antineoplastic Agents
  • Mesylates
  • Busulfan