Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

S J Conway; J C Miller; P A Howson; B P Clark; D E Jane

doi:10.1016/s0960-894x(01)00052-x

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

Bioorg Med Chem Lett. 2001 Mar 26;11(6):777-80. doi: 10.1016/s0960-894x(01)00052-x.

Authors

S J Conway¹, J C Miller, P A Howson, B P Clark, D E Jane

Affiliation

¹ Department of Pharmacology, School of Medical Sciences, Bristol, UK.

PMID: 11277518
DOI: 10.1016/s0960-894x(01)00052-x

Abstract

The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Excitatory Amino Acid Antagonists / chemical synthesis*
Excitatory Amino Acid Antagonists / chemistry
Excitatory Amino Acid Antagonists / pharmacology
Female
Glycine / analogs & derivatives*
Glycine / chemical synthesis*
Glycine / chemistry
Glycine / pharmacology
Male
Rats
Rats, Wistar
Receptors, Metabotropic Glutamate / antagonists & inhibitors*
Receptors, Metabotropic Glutamate / metabolism
Structure-Activity Relationship

Substances

Excitatory Amino Acid Antagonists
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor 3
phenylglycine chloride
Glycine