Cyclopenta-polycyclic aromatic hydrocarbons: potential carcinogens and mutagens

P P Fu; F A Beland; S K Yang

doi:10.1093/carcin/1.8.725

Cyclopenta-polycyclic aromatic hydrocarbons: potential carcinogens and mutagens

Carcinogenesis. 1980 Aug;1(8):725-7. doi: 10.1093/carcin/1.8.725.

Authors

P P Fu¹, F A Beland, S K Yang

Affiliation

¹ National Center for Toxicological Research, Jefferson, AR 72079, USA.

PMID: 11272127
DOI: 10.1093/carcin/1.8.725

Abstract

Cyclopenta-polycyclic aromatic hydrocarbons (cyclopenta-PAHs) are a group of compounds that have been detected as environmental pollutants. Perturbation molecular orbital (PMO) calculations on their presumed ultimate carcinogenic metabolites, the cyclopenta-PAH expoxides, predict that they may have a greater biological hazard than the classic PAHs.

MeSH terms

Animals
Carcinogens / chemistry
Carcinogens / toxicity*
Cyclopentanes / chemistry
Cyclopentanes / toxicity*
Epoxy Compounds / chemistry
Epoxy Compounds / toxicity*
Humans
Molecular Structure
Mutagens / chemistry
Mutagens / toxicity*
Polycyclic Aromatic Hydrocarbons / chemistry*
Polycyclic Aromatic Hydrocarbons / toxicity
Structure-Activity Relationship

Substances

Carcinogens
Cyclopentanes
Epoxy Compounds
Mutagens
Polycyclic Aromatic Hydrocarbons